Role of the <i>GRIN1</i> gene polymorphism in the formation of post-traumatic epilepsy

Introduction: NMDA receptors are involved in the pathogenesis of seizures, as it subunit is coded for by GRIN1 gene. Different mutations known patients with different forms epilepsy and encephalopathy. However, no data available on participation gene its polymorphisms development post-traumatic (PTE). Aim: To determine influence single-nucleotide rs1126442 polymorphism risk PTE formation. Materials methods: A total 140 were examined, which included 69 71 genetic epilepsy. All underwent a comprehensive examination, evaluation history, neurological status, electroencephalography (EEG) neuroimaging results, genotyping blood samples real-time polymerase chain reaction. The control sample examination was venous from 60 healthy individuals. Results: Focal seizures transition to bilateral tonicclonic predominant group. Neuroimaging revealed dystrophic, cystic, cystogliotic alterations signs external hydrocephaly. EEG recorded interictal ictal epileptiform activity slowing theta waves. Genotyping predominance heterozygous G/A homozygous A/A genotypes codominant (odds ratio (OD)=3.43; 95% confidence index (CI) 1.567.55; p=0.0047), dominant (OR=3.24; CI 1.576.68; p=0.0011), superdominant (OR=2.90; 1.366.22; p=0.0048) inheritance models. carriage genotype associated an all (OR=2.40; 1.115.20; p=0.024). Conclusion: rs 1126442 models high after craniocerebral trauma. EEG.